{"id":2695,"date":"2026-02-26T08:42:36","date_gmt":"2026-02-26T07:42:36","guid":{"rendered":"https:\/\/www.mammaprint.cz\/2026\/02\/26\/sucasne-a-buduce-moznosti-genomickeho-testovania-v-ranom-stadiu-er-pozitivneho-karcinomu-prsnika\/"},"modified":"2026-02-27T08:19:32","modified_gmt":"2026-02-27T07:19:32","slug":"sucasne-a-buduce-moznosti-genomickeho-testovania-v-ranom-stadiu-er-pozitivneho-karcinomu-prsnika","status":"publish","type":"post","link":"https:\/\/www.mammaprint.cz\/sk\/2026\/02\/26\/sucasne-a-buduce-moznosti-genomickeho-testovania-v-ranom-stadiu-er-pozitivneho-karcinomu-prsnika\/","title":{"rendered":"S\u00fa\u010dasn\u00e9 a bud\u00face mo\u017enosti genomick\u00e9ho testovania v ranom \u0161t\u00e1diu ER-pozit\u00edvneho karcin\u00f3mu prsn\u00edka"},"content":{"rendered":"

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Pozrite si z\u00e1znam predn\u00e1\u0161ky prof. Adama Brufsk\u00e9ho<\/strong>, ktor\u00e1 bola prednesen\u00e1 v r\u00e1mci konferencie Prague ONCO 2026<\/strong>.<\/p>\n

Profesor Brufsky je renomovan\u00fd klinick\u00fd onkol\u00f3g \u0161pecializuj\u00faci sa na rakovinu prsn\u00edka, ktor\u00fd p\u00f4sob\u00ed na Univerzite v Pittsburghu a v UPMC Hillman Cancer Centre. Dlhodobo sa venuje genomick\u00e9mu testovaniu, personalizovanej lie\u010dbe a prekladu molekul\u00e1rnej biol\u00f3gie do klinickej praxe.<\/p>\n<\/div>\n

[\/et_pb_text][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=eak8tKaCdA0″ image_src=”\/\/i.ytimg.com\/vi\/eak8tKaCdA0\/hqdefault.jpg” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_video][et_pb_text _builder_version=”4.27.4″ text_font_size=”16px” header_2_font=”Roboto|700|||||||” header_2_font_size=”45px” header_2_line_height=”1.2em” header_3_text_color=”#f05da3″ max_width=”970px” max_width_last_edited=”off|desktop” module_alignment=”center” custom_margin=”|||” custom_padding=”|||” header_2_font_size_tablet=”35px” header_2_font_size_phone=”28px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Stru\u010dn\u00e9 zhrnutie k\u013e\u00fa\u010dov\u00fdch posolstiev<\/strong><\/h3>\n

Predn\u00e1\u0161ka prof. A. Brufsk\u00e9ho nazna\u010duje, \u017ee ako Oncotype DX, tak aj MammaPrint plnia svoj z\u00e1kladn\u00fd \u00fa\u010del pri rozhodovan\u00ed o indik\u00e1cii chemoterapie. Prof. Brufsky v\u0161ak z\u00e1rove\u0148 poukazuje na to, \u017ee niektor\u00e9 inform\u00e1cie poskytovan\u00e9 testom Oncotype DX je mo\u017en\u00e9 do ur\u010ditej miery odhadn\u00fa\u0165 v praxi na z\u00e1klade vysoko kvalitn\u00fdch klinicko-patologick\u00fdch parametrov a imunohistoch\u00e9mie<\/strong> (tzv. McGeeho rovnica \u2013 napr. ER\/PR\/HER2, Ki-67, ve\u013ekos\u0165 n\u00e1doru, stupe\u0148\/Nottinghamsk\u00e9 sk\u00f3re). Naopak, opakovane zd\u00f4raz\u0148uje pridan\u00fa hodnotu, ktor\u00fa pon\u00faka MammaPrint a ktor\u00fa Oncotype DX v s\u00fa\u010dasnosti neposkytuje<\/strong>: identifik\u00e1ciu ultra-n\u00edzkeho rizika a diferenci\u00e1ciu vysok\u00e9ho rizika na vysok\u00e9-1 a vysok\u00e9-2, pri\u010dom tieto podskupiny maj\u00fa odli\u0161n\u00e9 biologick\u00e9 spr\u00e1vanie a odli\u0161n\u00e9 predpovede reakcie na lie\u010dbu. V praktickom zmysle sa uv\u00e1dza, \u017ee najm\u00e4 skupina high-2 sa biologicky spr\u00e1va \u201eagres\u00edvnej\u0161ie\u201c a je spojen\u00e1 s vy\u0161\u0161ou pravdepodobnos\u0165ou pCR v neoadjuvantnej terapii a v\u00e4\u010d\u0161\u00edm pr\u00ednosom z intenz\u00edvnej\u0161ej syst\u00e9movej lie\u010dby. Z\u00e1rove\u0148 prezentuje \u00fadaje podporuj\u00face potenci\u00e1lne vyu\u017eitie tejto stratifik\u00e1cie pri zva\u017eovan\u00ed pr\u00ednosov antracykl\u00ednov, imunoterapie a v bud\u00facnosti aj pri lep\u0161om v\u00fdbere pacientov na adjuvantn\u00fa lie\u010dbu inhib\u00edtormi CDK4\/6. Diskusia okrem in\u00e9ho otvorila aj ot\u00e1zku pou\u017eitia testu u pacientiek v premenopauze<\/strong> v kontexte interpret\u00e1cie, ktor\u00e1 sa niekedy objavuje v praxi, \u017ee Oncotype DX je \u201evhodnej\u0161\u00ed\u201c pre \u017eeny v premenopauze. Profesor Brufsky v\u0161ak jasne uviedol, \u017ee MammaPrint sa be\u017ene pou\u017e\u00edva u \u017eien v premenopauze aj po menopauze a \u017ee pri biologickom porovnan\u00ed n\u00e1dorov medzi t\u00fdmito dvoma skupinami nevid\u00ed \u017eiadne rozdiely, ktor\u00e9 by z praktick\u00e9ho h\u013eadiska obmedzovali pou\u017eitie MammaPrint u pacientok v premenopauze.\u00a0<\/p>\n

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Samotn\u00fd menopauz\u00e1lny stav nie je d\u00f4vodom na uprednostnenie testu Oncotype DX \u2013 test MammaPrint je preto vhodn\u00fd aj pre pacientky v premenopauze.<\/strong><\/p>\n

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Pozrite si z\u00e1znam predn\u00e1\u0161ky prof. Adama Brufsk\u00e9ho, ktor\u00e1 bola prednesen\u00e1 v r\u00e1mci konferencie Prague ONCO 2026. Profesor Brufsky je renomovan\u00fd klinick\u00fd onkol\u00f3g \u0161pecializuj\u00faci sa na rakovinu prsn\u00edka, ktor\u00fd p\u00f4sob\u00ed na Univerzite v Pittsburghu a v UPMC Hillman Cancer Centre. Dlhodobo sa venuje genomick\u00e9mu testovaniu, personalizovanej lie\u010dbe a prekladu molekul\u00e1rnej biol\u00f3gie do klinickej praxe. Stru\u010dn\u00e9 zhrnutie […]<\/p>\n","protected":false},"author":2,"featured_media":2679,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[30,31,29],"tags":[],"class_list":["post-2695","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blueprint-sk","category-clanky-pre-profesionalov","category-mammaprint-sk"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t